I HAVE RECENTLY READ - Metformin use in nondiabetic obese pregnant women does not improve neonatal outcome (February 2016)

• Metformin use in nondiabetic obese pregnant women does not improve neonatal outcome (February 2016)


It has been hypothesized that administering metformin to nondiabetic obese pregnant women might reduce gestational weight gain and, in turn, pregnancy complications associated with obesity. In the Metformin in Obese Nondiabetic Pregnant Women randomized trial, metformin use in the second and third trimesters reduced gestational weight gain compared with placebo (4.6 versus 6.3 kg) and the rate of preeclampsia (3 versus 11.3 percent), but did not reduce the frequency of large for gestational age neonates or adverse neonatal outcomes [14]. Based on these and other recent data [15], we believe use of metformin in pregnancy should be limited to management of hyperglycemia. (See "Weight gain and loss in pregnancy", section on 'Metformin'.)

     

 
     

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