I HAVE RECENTLY READ - Platelet counts in neonatal alloimmune thrombocytopenia (April 2016)

• Platelet counts in neonatal alloimmune thrombocytopenia (April 2016)

In pregnancies with human platelet antigen (HPA)-1a incompatibility, data from retrospective studies suggest that fetal/neonatal platelet counts are lower in the second affected pregnancy. However, the only prospective study of neonatal platelet counts in 29 subsequent untreated pregnancies did not confirm this finding [4]. When the index pregnancy was complicated by neonatal alloimmune thrombocytopenia (NAIT), neonatal platelet counts in the subsequent pregnancy were the same or higher in two-thirds of cases. When the index pregnancy was complicated by NAIT with severe thrombocytopenia, neonatal platelet counts in the subsequent pregnancy were the same or higher in 29 percent of cases. These findings, if confirmed in larger studies, suggest that the severity of NAIT does not consistently worsen in subsequent pregnancies. (See "Neonatal alloimmune thrombocytopenia: Parental evaluation and pregnancy management", section on 'Background'.)

 

     

 
     

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